Obesity decreases excitability of putative ventral tegmental area GABAergic neurons

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Obesity decreases excitability of putative ventral tegmental area GABAergic neurons

Palatable food has reinforcing effects on feeding and accelerates obesity. Alteration of food-related behavior in obesity may promote maintenance of obesity. The ventral tegmental area (VTA) of the midbrain is important for food reward. However, it is unknown whether activity of VTA neurons is altered in diet-induced obesity. In this study, we examined VTA neuronal activity using an electrophys...

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Microinfusion of Bupropion Inhibits Putative GABAergic Neuronal Activity of the Ventral Tegmental Area

Introduction: The most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (DA). The increase of DA can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition. Although bupropion can decrease the dopamine release, there is evidence about stimulatory effects of chronic application o...

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Electrophysiological characterization of GABAergic neurons in the ventral tegmental area.

GABAergic neurons in the ventral tegmental area (VTA) play a primary role in local inhibition of mesocorticolimbic dopamine (DA) neurons but are not physiologically or anatomically well characterized. We used in vivo extracellular and intracellular recordings in the rat VTA to identify a homogeneous population of neurons that were distinguished from DA neurons by their rapid-firing, nonbursting...

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Identification of Rat Ventral Tegmental Area GABAergic Neurons

The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons. Although indirect evidence supports the neural circuit postulated by this model, its validity has been called into question by growing evidence for VTA neuronal ...

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microinfusion of bupropion inhibits putative gabaergic neuronal activity of the ventral tegmental area

introduction: the most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (da). the increase of da can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition. although bupropion can decrease the dopamine release, there is evidence about stimulatory effects of chronic application o...

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ژورنال

عنوان ژورنال: Physiological Reports

سال: 2013

ISSN: 2051-817X

DOI: 10.1002/phy2.126